WebFIGURE 1 Requirement of Shoc2 for EGF-induced activation of MEK and ERK.A, HeLa cells were transfected with either control or Shoc2-specific siRNA. Forty-eight hours after transfection, cells were lysed and subjected to immunoblot analysis using antibodies against Shoc2 or tubulin (left). The relative Shoc2 expression level was quantified (right). WebSHOC2 KIAA0862, SOC-2, SOC2, SUR-8, SUR8 This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. …

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Webbody, specifically recognizing phospho-Thr507 of SHOC2. Using this antibody, we found that pSHOC2-Thr507 and total SHOC2 were accumulated upon the treatment of MLN4924 in a dose-dependent manner in FBXW7 wild-type cells but to a much lesser degree in FBXW7 null cells (Figures S2A and S2B). To identify signal that could trigger SHOC2-Thr507 ... WebThe scaffold protein Shoc2 is a critical modulator of ERK1/2 signals, and mutations in the shoc2 gene lead to the human developmental disease known as Noonan-like syndrome with loose anagen... psl score updates today sa

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Web12 Dec 2013 · SHOC2 is mutated in Noonan syndrome and plays a key role in the activation of the ERK-MAPK pathway, which is upregulated in the majority of human cancers. SHOC2 functions as a PP1-regulatory protein and as an effector of MRAS. Here we show that SHOC2 and MRAS form a complex with SCRIB, a polarity protein with tumor suppressor … WebCompare Anti-Shoc2 Antibody Products from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more. WebMolecularly, SHOC2 is a scaffold protein that brings together activated Ras (activated via G-protein coupled receptors and the interaction of GTP to GDP) and Raf, which then facilitates the transfer of the phospho-Raf phosphate to other proteins for the activation of the MAP Kinase pathway for gene activation. horseradish antibacterial