WebNov 18, 2010 · ISG15 类泛素化修饰: 宿主细胞固有的抗病毒的新机制.pdf 2010-11-18 上传 统的表达, 暗示ISG15 共价修饰在机体抗病毒固有免疫反应中发挥重要作用。 WebOct 29, 2015 · ISG15 is strongly up-regulated by type I IFN ().As a ubiquitin-like modifier, ISG15 can form covalent conjugates to many cellular proteins, a process termed “protein ISGylation” (12, 13).A series of distinct enzymes are involved in the process of protein ISGylation, including ubiquitin-activating enzyme E1 homolog (UBE1L) (14, 15), a …
The diverse repertoire of ISG15: more intricate than initially …
WebApr 6, 2024 · 推测：ISGylation（一种类泛素化修饰）可能是DNA修复与囊泡分泌之间平衡杠杆的一个支点。 3. RNA处理因子THRAP3（同时也是外泌体蛋白）和BCLAF1对RNA-DNA杂交链动态和DNA修复非常重要，抑制癌细胞囊泡分泌可降低癌细胞对化疗的抵抗力，其中PD-L1和THRAP3可能是关键 ... WebAug 10, 2024 · During infection, pathogen sensing and cytokine signaling by the host induce expression of antimicrobial proteins and specialized post-translational modifications. One … galaxy chesterfield 14
The in vivo ISGylome links ISG15 to metabolic pathways and ... - X …
WebInterferon-stimulated gene 15 ( ISG15) is a 17 kDA secreted protein that in humans is encoded by the ISG15 gene. [5] [6] ISG15 is induced by type I interferon (IFN) and serves many functions, acting both as an extracellular cytokine and an intracellular protein modifier. The precise functions are diverse and vary among species but include ... WebSep 15, 2024 · ISGylation-mediated protein inactivation could be effective even when only a small fraction of the protein is modified if the modified protein acts as a dominant … WebAug 1, 2024 · A: 由于聚乙二醇产品用于不同实验，往往需要特定的条件，所以无法提供详细的产品使用说明和操作步骤。不过，我们已经收集了许多刊物报道的有关产品使用和实验细节。请访问聚乙二醇修饰参考文献，并选择合适的期刊进行参考。 Q: 能提供哪些PEG产品? A: 我们提供国内一流水准的聚乙二醇修饰 ... blackberry logo history