Inthomycin b
WebInthomycin B (1) and its two new analogues 2 and 3 were isolated from the crude extract of Streptomyces pactum L8. Identification of the gene cluster for inthomycin biosynthesis … WebOct 19, 2024 · Search life-sciences literature (Over 39 million articles, preprints and more)
Inthomycin b
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WebSep 21, 2024 · The structure of lincomycin A consists of the unusual eight-carbon thiosugar core methyllincosamide (MTL) decorated with a pendent N-methylprolinyl moiety.Previous studies on MTL biosynthesis have suggested GDP-ᴅ-erythro-α-ᴅ-gluco-octose and GDP-ᴅ-α-ᴅ-lincosamide as key intermediates in the pathway.However, the enzyme-catalyzed … Web因此，我们扩大了该菌株的发酵规模，对发酵液中的次级代谢产物进行提取分离，得到了5 个化合物，结构分别鉴定为:N-乙酰酪胺(1)、N-乙酰色胺(2)、吡咯-2-甲酰胺(3)、Inthomycin C(4)和Inthomycin B(5)(见图1)，并对其抗真菌和抗细菌活性进行筛选，旨在确定其中的抗菌 …
WebJan 7, 2014 · (+)-Inthomycin A (211), (+)-inthomycin B (212), and (−)-inthomycin C (213), oxazole-triene antibiotics, are significant and important targets for the total synthesis via the Stille coupling. Compound 211 can be synthesized through the Stille coupling between stannane 214 and Z , Z -iododiene 215 using Pd(PPh 3 ) 4 , CuI, and CsF to … WebSep 1, 2024 · Inthomycins are polyketide antibiotics which contain a terminal carboxamide group and a triene chain. Inthomycin B (1) and its two new analogues 2 and 3 were isolated from the crude extract of Streptomyces pactum L8.Identification of the gene cluster for inthomycin biosynthesis as well as the 15 N-labeled glycine incorporation into …
WebSep 12, 2012 · Inthomycin B (1) and its two new analogues 2 and 3 were isolated from the crude extract of Streptomyces pactum L8. Identification of the gene cluster for inthomycin biosynthesis as well as the ... WebOct 1, 2024 · Moreover, the disruption/complementation experiments of itm15 also resulted in the loss and restoration of inthomycin A and B formation. Further gene cloning, …
WebMay 28, 2024 · Compound 9 exhibited significant antimicrobial activities towards B. cinerea, F. graminearum, S. aureus, and MRSA with MICs of ... Wang B-X, Li X, Yue S-P, Chen J-W, Zhang H-W, Wang H (2024) Production and identification of inthomycin B produced by a deep-sea sediment-derived Streptomyces sp YB104 based on cultivation-dependent ...
WebThe quantification of inthomycin B demonstrated that Streptomyces sp. YB104 produced moderate yield of inthomycin B with a yield around 25 mg/l after 14 days. Thus, … c# classes and methodsWebOct 19, 2010 · The synthetic utility of this methodology was demonstrated in the first short synthesis of naturally occurring inthomycin C in high enantiopurity. A cationic oxazaborolidinium-catalyzed asymmetric Mukaiyama aldol reaction of (1-methoxy-2-methyl-propenyloxy)-trimethylsilane with various aldehydes including α,β-disubstituted acroleins … c classes freeWebStereochemical evidence is presented to demonstrate that (−)-inthomycin C has (3R)- and not (3S)-stereochemistry. Careful reappraisal of the previously published work2−5 now indicates that the Hatakeyama, Hale, Ryu, and Taylor teams all have synthesized (−)-(3R)-inthomycin C. The newly measured [α]D of pure (−)-(3R)-inthomycin C (98% ee) is … bus to denver airport from boulderWebmoderate yield of inthomycin B with a yield around 25 mg/l after 14 days. Thus, Streptomyces sp. YB104 was considered to be a useful potential as a first industrial … bus to deptford mallWebOct 19, 2024 · The isolation of inthomycin A was first reported by Ōmura in 1990 1 who subsequently reported the isolation of inthomycins B and C in 1995. 2 Between these … c class engineWebJan 23, 2006 · A concise, convergent and stereocontrolled synthesis of (+)-inthomycin B, based on the Stille coupling of a stannyl-diene with an oxazole vinyl iodide unit, is … bus to denver airport from colorado springsWebThe geometrically different triene units for each inthomycin were stereoselectively established via methyl cuprate conjugate addition, isomerization of the α,β-unsaturated … bus to derby from nottingham